Abstract
From bacteria to higher vertebrates, cells have developed different systems to communicate with each other and transmit specific signals in a dynamic interplay with neighborhood cells. This review focuses on cell-to-cell communication mediated by nanotubes, membrane protrusions present during evolution from bacteria to higher plants and animals. We describe the basic structure of nanotubes in different organisms and cell types and their functions, which cover transfer of signaling molecules, ions, organelles and pathogens in a cell- and context-dependent manner, thereby promoting cell survival, tissue development, response to stress, pathogens' spreading and drug resistance. We also provide an overview of recent studies that are broadening our understanding of the role of these conduits in the pathogenesis of high-incidence diseases in humans, such as cancer and neurodegeneration.