Abstract
Organ-on-a-chip (OoC) or tissue-on-a-chip (ToC) technologies represent a significant advancement in enabling modeling of human organ and tissue physiology for medical study, although further development is required for these technologies to reach widespread adoption. OoC/ToC are three-dimensional (3D) microfluidic platforms that overcome limitations of traditional two-dimensional (2D) cell culture or animal models, providing an alternative environment for disease study, drug interactions, and tissue regeneration. The design of these systems is complex, requiring advanced fabrication techniques and careful selection of biomaterials with consideration of material toxicity, optical clarity, stability, and flexibility. A key innovation in this field is the multi-organ-on-a-chip (MOC) technology, which links multiple organ systems on a single platform. This enables the study of systemic diseases and the complex communication between organs, which is not possible with single-organ models. Furthermore, OoC/ToC technology holds immense potential for personalized medicine. By using patient-specific cells, these devices can create disease models that reflect an individual's unique genetic and phenotypic variations, paving the way for tailored therapeutic interventions. The integration of real-time sensors within these devices also facilitates high-throughput screening and accelerates drug discovery. While the development and optimization of these systems is still in its early stages, OoC/ToC technologies have already demonstrated promise in a number of translational research applications.