Abstract
Oral health disparities are closely linked to broader health inequalities, particularly in global health contexts where disproportionate emphasis is placed on diseases other than oral health. In the field of dental genetics, recent investigations have highlighted persistent challenges and barriers in African genomic research. Colonial legacies continue to influence the structuring of research agendas and contribute to the marginalization of indigenous knowledge systems. We discuss the implications of these historical dynamics for the relevance of genetic research findings, and addresses the emerging ethical considerations in clinical applications and community engagement. We emphasize the need for equitable and culturally inclusive approaches to expand our genetic understanding of dental pathologies in underrepresented African populations.