Abstract
This review catalogs candidate LUAD driver genes and their roles, recent discoveries, and therapeutic avenues. Beyond experimental repurposing, we evaluate modern computational methods and how they complement bench work. We conclude by appraising recent LUAD repurposing studies through a computational lens, emphasizing practical integration into translational research. Highlights: Overview of drug repurposing methods: We provide a list of six experimental and a brief taxonomy of eight computational drug repurposing method families. Recent insights into LUAD driver genes: We present a curated panel of LUAD drivers mapped to pathways, with alteration types, functions, and therapeutic implications. LUAD-focused computational repurposing studies: We provide a synthesis of recent LUAD studies presenting clear method families, highlighting exemplar pipelines, prioritized candidate drugs, and datasets.