Abstract
Binge drinking is a relatively common pattern of alcohol use among youth with normative trajectories peaking in emerging and early adulthood. Frequent binge drinking is a critical risk factor not only for the development of alcohol use disorders (AUDs) but also for increased odds of alcohol-related injury and death and thus constitutes a significant public health concern. Changes in binge drinking across development are strongly associated with individual differences and changes in impulsive personality traits, which have been hypothesized as intermediate phenotypes associated with genetic risk for heavy alcohol use and AUD. The current study examined the extent to which genetic influences underlying dual-systems impulsive personality traits (i.e., top-down [lack of self-control] and bottom-up [sensation seeking and urgency] constructs), alcohol consumption, and AUD are uniquely associated with longitudinal changes in binge drinking and intoxication frequency across adolescence and early adulthood. Associations were tested using conditional latent growth curve polygenic score (PGS) models in three independent longitudinal samples (N = 10,554). Results demonstrated consistent associations across all samples between sensation seeking PGSs and model intercepts (i.e., higher binge drinking frequency at first measurement occasion) and alcohol consumption PGSs and model slopes (i.e., steeper increases toward peak binge drinking frequency). Urgency PGSs were not associated with changes in binge drinking or intoxication frequency in any sample. Collectively, these findings demonstrate that genetic influences underlying sensation seeking and alcohol consumption explain unique variation in the emergence and escalation of binge drinking during adolescence and emerging adulthood, highlighting the multifaceted genetic etiology of these developmental trajectories. (PsycInfo Database Record (c) 2025 APA, all rights reserved).