Abstract
Clear cell papillary renal cell carcinoma (CCPRCC) was included as a separate entity in the World Health Organisation classification of renal tumours in 2016. Immuno-histopathological and genetic characteristics are much known, but still, clinical features and long-term follow-up require more consolidated data. We report three cases of CCPRCC, detected in different clinical settings. The first case was co-incidentally diagnosed on routine imaging, in a follow-up case of open cystolithotripsy. The second case presented with haematuria under evaluation; and the third case presented with mild thrombocytopenia without anaemia or a positive Coombs test. All the cases revealed characteristic histopathological examination and immunohistochemistry. None of the patients showed tumour recurrence/metastases on follow-up. The study holds importance as it presents CCPRCC cases in different clinical scenarios, describes a rarely reported case of thrombocytopenia without associated anaemia/positive Coombs test, and emphasises the need to consider CCPRCC in relevant clinico-radiological settings and immuno-histopathological features, due to its indolent nature and consequently better prognosis.