Abstract
Radiometals have been commonly used in medical applications, and utilization of such metals continues to be an attractive research area. In particular, a variety of radiometals have been developed and implemented for molecular imaging. For such applications, (89)Zr has been one of the most interesting radiometals currently used for tumor targeting. Several chemical ligands were developed as (89)Zr chelators, and new coordinating methods have also been developed more recently. In addition, immuno-positron emission tomography (PET) studies using (89)Zr-labeled monoclonal antibodies have been performed by several scientists. In this review, recent advances to the coordination of (89)Zr and the utilization of (89)Zr in PET studies are described.