Abstract
BACKGROUND: Respiratory Syncytial Virus (RSV) is a leading cause of hospitalisation in infants worldwide. While the clinical implications of RSV are well-documented, the societal impact due to burden of illness absorbed by families remains underexplored. This study aims to quantify the burden on parents of infants aged 0–6 months hospitalised due to RSV infection during the 2022–2023 season in Denmark. METHODS: A cross-sectional survey was conducted among parents of infants hospitalised with RSV. The survey included questions on the extension of parental leave, work and educational absenteeism, financial expenses related to medication, and the need for extended family support. The response rate was 29%, with 379 parents participating corresponding to 111 respondents. RESULTS: Nearly half of the respondents (47.6%) reported extending their parental leave due to their child’s RSV hospitalisation, with the majority extending leave for 1–6 days. Work or educational absenteeism was reported by 24% of parents and 27% of their partners. Financially, 83% of parents faced additional expenses for medication. The study also found that 61% of families required support from family members, while few received assistance from local authorities. Based on the survey data, an estimated 2,484 to 10,416 workdays are lost due to RSV hospitalisations per season, indicating a significant societal cost. CONCLUSIONS: The socioeconomic impact of RSV hospitalisations extends beyond the immediate health implications for the infant. The findings reveal a substantial burden on parents, including extended leave, absenteeism, and financial costs. The study highlights the need to include burden on informal care givers when evaluating the burden of disease for infants and facilitate to reduce this burden. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12889-025-25926-9.