Abstract
BACKGROUND: Undiagnosed diabetes mellitus (uDM) impacts millions of people worldwide, posing significant public health and healthcare challenges. Understanding socio-demographic, health, and healthcare factors associated with uDM is essential for reducing its prevalence, mitigating regional disparities, and enhancing early detection strategies. Since early identification of undiagnosed cases ensures timely treatment and slows the progression of complications, it saves high cost for healthcare systems. METHODS: Our survey focuses on people aged 50 years and older. Based on data from the Survey of Health, Ageing, and Retirement in Europe (SHARE, Wave 6 in 2015) in 11 European countries and Israel, we combine dried blood spot (DBS) results with self-reported diabetes diagnoses to identify uDM cases. Harmonized blood spot collection and analysis across the SHARE countries enhanced the international comparability of findings. Weighted logistic regressions were applied to study factors associated with uDM compared with normoglycemia, pre- and diagnosed diabetes mellitus (dDM). RESULTS: The prevalence of uDM in individuals aged 50 + in the SHARE countries in 2015 is 7.2%, representing 34.2% of all diabetes cases. Combined with 14.0% dDM, the total prevalence of diabetes is 21.2%. Mediterranean countries showed a higher uDM prevalence compared to northern and central European countries, ranging from 5.0% in Denmark to 14.8% in Greece. Compared to people without diabetes, undiagnosed individuals had a lower socio-economic status (SES) and were more likely to be obese and hypertensive, yet they self-rate their health similarly to those without diabetes. Compared to people diagnosed with diabetes, undiagnosed share a similar SES, but they are younger, report fewer health problems, and generally self-rate their health better. CONCLUSION: Early detection of diabetes is underdeveloped in Europe, with significant regional disparities. Individuals with uDM often underestimate their risks due to the asymptomatic nature of the disease in its early stages, highlighting the need for targeted public health interventions beyond the typical risk groups. Our results suggest that diabetes awareness and effective screening for uDM still need to be increased, particularly among younger and seemingly healthy individuals, those with lower SES, obesity, and hypertension.