Abstract
BACKGROUND: Research indicates a positive association between short-term diurnal temperature range (DTR) exposure and hypertension. However, the impact of long-term DTR exposure has not been thoroughly studied in population-based cohort research. METHODS: This study conducted cross-sectional (including 16,690 participants) and longitudinal analyses (including 9,650 participants) based on the China Health and Retirement Longitudinal Study (CHARLS). Daily temperature data was sourced from the National Scientific Data of the Qinghai-Tibet Plateau. We calculated the moving average of DTR exposure of all the participants in CHARLS with exposure windows of 30-day, 60-day, 180-day, 1-year, and 2-year before the interview month of CHARLS Wave1 (2011). Logistic regression and age-stratified Cox proportional hazards models were employed in our analysis. RESULTS: In the cross-sectional study, 6,572 (39.4%) participants had hypertension. We found higher DTR is associated with a higher prevalence of hypertension across different exposure windows. The effect was strongest when the exposure window of DTR was 180-day, with an adjusted odds ratio (OR) of 1.261 (95% confidence interval (CI): 1.124-1.416 [highest tertile DTR vs. lowest tertile DTR]). In the cohort study, 3,020 (31.3%) participants developed hypertension during 83 months of follow-up. A higher level of DTR (hazard ratio (HR): 1.224, 95% CI: 1.077-1.391) was associated with a higher risk of incident hypertension. We found significant interactions between DTR and age (P interaction: <0.001) and residence (P interaction: 0.045). CONCLUSION: We found significant positive associations between DTR and prevalent and incident hypertension. Individuals younger than 65 and those living in rural areas are at an elevated risk of developing hypertension due to DTR.