Abstract
Cells respond to mechanical stimulation by activation of specific signaling pathways and genes that allow the cell to adapt to its dynamic physical environment. How cells sense the various mechanical inputs and translate them into biochemical signals remains an area of active investigation. Recent reports suggest that the cell nucleus may be directly implicated in this cellular mechanotransduction process. Taken together, these findings paint a picture of the nucleus as a central hub in cellular mechanotransduction-both structurally and biochemically-with important implications in physiology and disease.