Abstract
OBJECTIVE: To investigate the patterns of human papillomavirus (HPV) genotype distribution and identify high-risk factors for HPV infection, focusing on their etiological significance and potential public health implications. METHODS: This study enrolled 496 women from the Gynecology Outpatient Department of Wuhan Central Hospital between September 2021 and September 2024. Data were collected through medical records and questionnaire surveys to analyze the distribution characteristics of HPV infection. High-risk factors were evaluated using multivariate binary logistic regression analysis. RESULTS: HPV infection exhibited the highest infection rate among women ≤25 years (63.5%) and ≥49 years (55.0%), with the most common types of high-risk HPV being HPV52, 16, and 58. Protective factors included frequent condom use (odds ratio [OR]=0.580) and HPV vaccination (OR=0.564). High-risk factors included diabetes (OR=6.620), anxiety (OR=2.126), and low work intensity (OR=1.670). CONCLUSION: This study demonstrated diabetes, anxiety, and low work intensity as significant risk factors for HPV infection, providing valuable etiological insights. Psychological assessments and diabetes management should be integrated into public health strategies for HPV prevention. Furthermore, multidisciplinary collaboration among gynecologists, psychologists, and endocrinologists, is also recommended to prevention and care efforts.