Abstract
Transgender (TG) individuals represent a growing yet underserved community with unique healthcare challenges, particularly their increased vulnerability to sexually transmitted infections. This case series assesses the clinico-epidemiological profile of five TG patients attending the Suraksha clinic at a tertiary hospital in Northern India. Key risk factors include early sexual debut, limited education, and inconsistent substance use. Diagnosed infections include syphilis, genital warts, and anal herpes. Despite access to healthcare, 60% of patients were lost to follow-up. Active surveillance in high-risk areas, along with psychological and medical support, may improve health outcomes by addressing socioeconomic and educational barriers.