Abstract
Human papillomavirus (HPV) can cause a range of diseases, the most common being cervical cancer. Although vaccines have existed for decades and are highly effective at preventing the illness, vaccination coverage is low, specifically among adolescents. There has been some success in vaccination campaigns in the UAE among girls, but very low male adolescent vaccination rates. It is essential to identify vaccination patterns as well as predictors of uptake to improve public health outcomes. This narrative review included relevant studies published between 2005 and 2025 in the PubMed, Scopus, Google Scholar, ScienceDirect, and Embase databases. The MeSH terms used were "Human Papillomavirus vaccine," "HPV vaccine," "Human Papillomavirus," "HPV," "vaccine uptake," "immunization," and "United Arab Emirates." Following the introduction of HPV vaccination in adolescent girls in 2008, the UAE saw a dramatic expansion of coverage, with some areas exceeding 90%. However, recent trends show the number of adolescents initiating vaccination has declined while completion is rising. Male data are limited but demonstrate very low coverage. Determinants of the uptake of vaccines include awareness levels, religious and cultural attitudes, fear of side effects, and concerns about costs and availability of the vaccine. Doctor referral was an extremely powerful motivator for vaccination. The UAE is behind its immediate regional neighbors in the uptake of vaccines, but leads when compared to international standards. While the UAE has shown tremendous improvement in HPV vaccination, there remains some room for growth, especially in male adolescents. Expanding education, drifting from cultural resistance to vaccination, and increasing vaccine availability are measures that are crucial to optimizing vaccine distribution and reducing HPV-related illnesses in the years ahead.