Sesquiterpenoid tropolone glycosides from Liriosma ovata

美洲金花菜中的倍半萜类托品酮糖苷

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作者:Jun Ma, Rahul S Pawar, Erich Grundel, Eugene P Mazzola, Clark D Ridge, Takashi Masaoka, Stuart F J Le Grice, Jennifer Wilson, John A Beutler, Alexander J Krynitsky

Abstract

Two new sesquiterpenoid tropolone glycosides, liriosmasides A (1) and B (2), along with two known compounds, secoxyloganin and oplopanpheside C, were isolated from a methanol extract of the roots of Liriosma ovata. The structures of 1 and 2 were elucidated by spectroscopic methods including 1D and 2D NMR and by high-resolution mass spectrometry involving an ultra-high-performance liquid chromatography-quadrupole-orbital ion trap mass spectrometric (UHPLC-Q-Orbitrap MS) method. Compound 1 showed weak inhibitory activity against HIV RNase H.

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