Abstract
INTRODUCTION: Post-exposure prophylaxis (PEP) for HIV, a form of emergency prevention, has been available for more than two decades. However, information about its use among trans women, a group disproportionately affected by HIV, is limited. OBJECTIVE: To explore knowledge, barriers, access facilitators, and use of PEP in trans women. METHOD: A qualitative study was carried out with 90 trans women in Goiânia, Central-West of Brazil, using semi-structured interviews and analyzed using thematic analysis. RESULTS: Participants had prior knowledge about PEP, although many did not understand its application and effectiveness. Despite knowing there were structural and psychosocial barriers that proved to be significant impediments to access and effective use of PEP. CONCLUSION: There is a need to develop inclusive public health strategies that meet the needs of trans women to improve access to and use of PEP. Continuing education and awareness initiatives are crucial to dispelling myths and providing accurate information about prophylaxis options. These are essential for both the trans community and health professionals, aiming to reduce the incidence of HIV in this vulnerable and often marginalized group. The implementation of such measures can facilitate greater adherence to PEP, contributing to the health and well-being of trans women.