Abstract
BACKGROUND: Health care providers are critical for successful implementation of HIV preexposure prophylaxis (PrEP), but barriers to PrEP provision persist. Researchers must engage with providers to understand how to optimize PrEP delivery across settings. Yet researcher-provider collaborations can be challenging. To offer guidance on engaging providers in PrEP implementation research, we synthesized the experiences of researchers working with different types of providers on studies related to PrEP implementation that were funded as part of the US Ending the HIV Epidemic (EHE) initiative. SETTING: Geographic areas designated as high priority by the EHE initiative. METHODS: We defined providers broadly, including physicians, pharmacists, health educators, and peer navigators. Using thematic analysis from collaborative case reports by EHE study teams, we synthesized strategies, challenges, and successes related to provider engagement, with categorization into three stages of research: study development, recruitment, and data collection. RESULTS: Among 17 research teams invited, 9 contributed. Findings suggested that extensive resources (eg, time, professional networks, financial, and nonfinancial incentives) are required to engage clinical and nonclinical providers across all stages of PrEP implementation research, with the most intensive strategies required for recruiting clinical providers who are not yet providing PrEP. However, when effective strategies are deployed, this investment of resources can yield rich insights into PrEP implementation. CONCLUSIONS: The lessons learned by the investigators in our study can be applied to future EHE-funded projects, other HIV-prevention studies, and studies in other areas of health research to improve engagement of providers during all stages of the research process.