Abstract
SARS-CoV-2 and its subvariants continue to spread globally. People living with HIV (PLWH), who have weakened immune systems, have heightened concerns about the virus. Thus, the relationship between COVID-19 and HIV remains unclear, and the risks of COVID-19 for PLWH have yet to be fully understood. The study conducted a retrospective cross-sectional survey on the Wenjuanxing platform to identify lifestyle risk factors and epidemic phenotypes associated with the severity of COVID-19 in PLWH. All respondents were over 18 years old and were receiving antiretroviral therapy. The survey included questions about their health status during the COVID-19 illness, and questions about basic sociodemographic information, lifestyle factors, and HIV treatment history. This study included 984 HIV patients with a mean age of 54.44 ± 14.4 years. Among the participants, 635 (64.53%) were male. A total of 33 (3.35%) respondents were unvaccinated, while 951 (96.65%) had received at least one vaccine dose, with 868 (88.21%) participants having received three or more vaccine doses. The association between the severity of COVID-19 symptoms and CD4 count (p = 0.652) and HIV viral load (p = 0.916) was found to be statistically insignificant. In reduced multivariate logistic model, passive smoking increased the risk of severe COVID-19 symptoms compared with non-smokers (odds ratios [OR] 1.66; 95% confidence interval [CI] 1.11-2.48). Mild (OR 2.23; 95% CI 1.55-3.24) and moderate/severe anxiety (OR 5.22; 95% CI 2.36-13.28) were also positively associated with severe COVID-19 symptoms compared to individuals with no anxiety. Comorbidity (OR 1.5; 95% CI 1.04-2.17) demonstrated a significant association with severe COVID-19 symptoms. Moderate/severe anxiety was significantly associated with a higher hospital admission rate (OR 2.62; 95% CI 1.27-5.37) compared to those without anxiety. Patients who consumed whole grains more than three times per week had a lower risk of hospital admission (OR 0.61; 95% CI 0.41-0.89). However, both anxiety and wholegrain intake were nonsignificant for hospitalization rates in individuals who tested positive for COVID-19 through real-time PCR or antigen test. In full multivariate logistic model for SARS-CoV-2 infection of hospitality, CD4 count (> 500 cells/mm(3)) (OR 0.64; 95% CI 0.41-0.99) and the CD4 count (200-500 cells/mm(3)) (OR 0.68; 95% CI 0.45-1.04) were significantly associated with hospital admission rates compared to CD4 count (< 200 cells/mm(3)), but the results were inconsistent in the reduced logistic models and analysis of Group B. This study indicates that anxiety is positively associated with worsened COVID-19 symptoms and higher hospitalization rates, suggesting a significant link between anxiety and the severity of COVID-19. However, the study did not find evidence of a correlation between CD4 count, HIV viral load, and the severity of COVID-19 or hospitalization rates.