Abstract
Understanding the complex dynamics of HIV/AIDS transmission requires models that capture real-world progression and intervention impacts. This study introduces an innovative mathematical framework using fractal-fractional calculus to analyze HIV/AIDS dynamics, emphasizing memory effects and nonlocal interactions critical to disease spread. By dividing populations into four distinct compartments-susceptible individuals, infected individuals, those undergoing treatment, and individuals in advanced AIDS stages-the model reflects key phases of infection and therapeutic interventions. Unlike conventional approaches, the proposed nonlinear transmission function, [Formula: see text], accounts for varying infectivity levels across stages (where [Formula: see text] is the total population and ∇ denotes the effective contact rate), offering a nuanced view of how treatment efficacy ([Formula: see text]) and progression to AIDS ([Formula: see text]) shape transmission. The analytical framework combines rigorous mathematical exploration with practical insights. We derive the basic reproduction number [Formula: see text] to assess outbreak potential and employ Lyapunov theory to establish global stability conditions. Using the Schauder fixed-point theorem, we prove the existence and uniqueness of solutions, while bifurcation analysis via center manifold theory reveals critical thresholds for disease persistence or elimination. We use a computational scheme that combines the Adams-Bashforth method with an interpolation-based correction technique to ensure numerical precision and confirm theoretical results. Sensitivity analysis highlights medication accessibility and delaying the spread of AIDS as a vital control strategy by identifying ([Formula: see text]) and ([Formula: see text]) as critical parameters. The numerical simulations illustrate the predictive ability of the model, which shows how fractal-fractional order affects outbreak trajectories and long-term disease burden. The framework outperforms conventional integer order models and produces more accurate epidemiological predictions by integrating memory-dependent transmission with fractional order flexibility. These findings demonstrate the model's value in developing targeted public health initiatives, particularly in environments with limited resources where disease monitoring and balancing treatment allocation is essential. In the end, our work provides a tool to better predict and manage the evolving challenges of HIV/AIDS by bridging the gap between theoretical mathematics and actual disease control.