Abstract
OBJECTIVE: To clarify the association between mesenchymal stromal cell exosomes (MSC-exosomes) and recurrent spontaneous abortion (RSA) Clarify the biological characteristics of MSC-exosomes and their potential regulatory functions in pregnancy maintenance. METHODS: By using the literature review method combined with the published relevant experimental research results, the biological characteristics of MSC-exosomes were systematically sorted out and analyzed to explore their potential mechanism of action in the process of pregnancy maintenance. The results show that MSC-exosomes can participate in the key processes of pregnancy maintenance by regulating the immune microenvironment at the maternal-fetal interface, promoting local angiogenesis and maintaining the normal physiological functions of trophoblast cells. The content of MSC-exosomes in the body shows a dynamic changing trend during pregnancy. A large number of studies have confirmed that MSC-exosomes are closely related to the establishment and maintenance of normal pregnancy and the occurrence and development of pathological pregnancy. CONCLUSION: In-depth exploration of the intrinsic association and mechanism of action between MSC-exosomes and RSA can provide a new perspective for the study of the pathogenesis of RSA, and at the same time offer potential biomarkers and therapeutic targets for the clinical diagnosis and targeted therapy of RSA, which has significant theoretical value and clinical significance.