Abstract
OBJECTIVE: This study aims to investigate the impact of T2DM on the seminal parameters of patients undergoing assisted reproduction techniques. METHODS: A retrospective analysis of medical records was conducted at the at our institution from January 2017 to January 2022, including data on patients age, presence of Type 1 or T2DM, prediabetes, and seminal parameters such as concentration, Kruger morphology, motility, pH, ejaculate volume, and sperm DNA fragmentation. RESULTS: Seminal parameters of patients with T2DM did not show significant differences compared to patients with normal controls. Conversely, evaluation of HbA1c as a continuous variable in our linear regression model indicated that this parameter was associated with elevated sperm DNA fragmentation. CONCLUSIONS: T2DM was not found to be a determining factor in the deterioration of overall seminal quality in patients undergoing assisted reproduction techniques, with a potential negative effect on sperm DNA fragmentation.