A Review of the Evidence of the Toxicity of Chemical Substances Included in the European Union Ambient Air Quality and Drinking Water Directives: Perspectives for Health Impact Assessments

The European Union (EU) Ambient Air Quality Directive (AAQD) and Drinking Water Directive (DWD) are aimed at maintaining and improving air quality and ensuring high standards for potable water across the EU. Besides several other indicators, the AAQD and DWD consist of chemical parameters (substances or substance groups) that are regulated within this framework. All the substances are associated with various health outcomes, and many of them are classified as carcinogenic or probably/possibly carcinogenic with causal links. To quantify the health burden of the chemical substances included in the AAQD and DWD, we need information regarding population exposure, current baseline mortality/morbidity rates in the populations, and exposure-response functions (ERFs) or unit risks (URs) from previous epidemiological studies. During this study, we analyzed the availability of ERFs or URs and discussed their applicability in health impact assessments (HIAs). From the HIA perspective, ERFsin terms of relative risk (RR), standardized mortality ratio (SMR), odds ratio (OR), or UR datawere available for many of the analyzed substances. However, for some substances such as acrylamide, antimony, boron, chlorate and chlorite, copper, microcystin-LR, and selenium, no risk measures could be identified. The aim of this study is to derive ERFs, which will allow HIAs for a larger number of chemicals when exposure data and baseline mortality/morbidity data are available. Currently, HIAs have largely focused only on main ambient pollutants such as particulate matter (PM(10)), fine particulate matter (PM(2.5)), nitrogen oxides (NO(X)), and ozone (O(3)). In contrast, health risks related to exposure to chemicals are much more diverse, and the health burdens should be quantified to a much greater extent.