Effect of COVID-19 inactivated vaccine on anti-Müllerian hormone in Chinese women: a retrospective cohort study

新冠病毒灭活疫苗对中国女性抗苗勒氏管激素的影响:一项回顾性队列研究

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Abstract

INTRODUCTION: This study aimed to assess the impact of inactivated COVID-19 vaccine on Anti-Müllerian hormone (AMH) levels in Chinese women. METHODS: A retrospective analysis was conducted on women aged 18-45 who had undergone two AMH tests between March 2020 and September 2021. Participants were grouped based on vaccine doses (two- and three-dose), time intervals since vaccination, and manufacturers. The difference in AMH levels and the percentage changes in AMH were measured. RESULTS: The results revealed no significant differences in AMH levels between the vaccinated groups (two- and three-dose) and the control group, both in unadjusted and adjusted analyses. Subgroup analysis showed no statistical difference in either absolute or percentage changes of AMH levels among different time-interval groups and manufacturer groups. DISCUSSION: In conclusion, the number of doses, time interval, and manufacturer of the inactivated COVID-19 vaccine did not affect AMH levels in Chinese women.

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