Abstract
PURPOSE: Based on the global burden of disease (GBD) data from 1990 to 2021, to systematically evaluate the spatiotemporal variation characteristics of the incidence, mortality, and disability-adjusted life years (DALYs) of lymphoma and its main subtypes (Hodgkin's lymphoma [HL], non-Hodgkin's lymphoma [NHL], and their subtypes). And explore the influence of the sociodemographic index (SDI) on the disease burden of lymphoma. METHODS: Using the GBD 2021 data covering 204 countries/regions worldwide, the age-standardized incidence rate (ASIR), mortality rate (ASDR), DALYs, and average annual percentage change rate (EAPC) were analyzed. The influence of socio-economic factors on the burden of lymphoma was revealed through SDI stratification, regional comparison, and gender-age analysis. RESULTS: The results showed that the incidence and mortality rates of HL and NHL in areas with high SDI were relatively high and on the rise, which might be related to the improvement of medical diagnosis levels. The burden of NHL in medium- and low-SDI regions is relatively low but gradually increasing. The incidence of Burkitt lymphoma (BL) and DALYs significantly increased in areas with high SDI, while the changes were relatively small in areas with medium and low SDI. The incidence and mortality rates of most subtypes in men are higher than those in women, and the burden varies significantly among different age groups. CONCLUSION: The socioeconomic level is closely related to the disease burden of lymphoma. It is necessary to strengthen global medical collaboration and resource allocation, especially to enhance the diagnosis and treatment capabilities in areas with low SDI. In the future, it is necessary to explore the interaction between environmental and genetic factors on lymphoma and formulate precise regional prevention and control strategies in order to reduce the disease burden and promote health equity.