Abstract
Healthcare professionals’ well-being is increasingly recognized as a critical organizational priority, given the risks posed by rising workloads, staff shortages, and burnout to the sustainable delivery of high-quality care. However, limited evidence exists on how work environments and technology adoption influence the healthcare professionals’ well-being across hospital settings. This study explores healthcare professionals’ perceptions of psychological and physical safety, professional engagement, and mental well-being. It also assesses the role of technology in fostering a culture of safety and well-being. A cross-sectional qualitative anonymous online survey was distributed across 13 countries in Europe, Middle East and Africa, targeting professionals working in hospital pharmacy, diagnostic laboratory, and ward settings. The questionnaire, available in five languages, included validated items. Data were analyzed using descriptive and inferential statistics, with subgroup analyses by setting and region. Responses were collected between February and August 2024. A total of 449 healthcare professionals participated. The sample presented a positive perception of psychological safety (61%) and professional engagement (55%). However, 27% of responders frequently experienced work-related stress, with 40% feeling exhausted, 25% reporting mental distance, and 23% cognitive impairment. Perceived physical safety was generally high (70%), although ward staff reported higher exposure to stress and interpersonal aggression. Overall, 58% of responders expressed satisfaction with their professional quality of life. Technology was perceived to enhance efficiency, safety, and collaboration. However, its impact was dependent on the quality of implementation and level of organizational support. Results may inform strategic interventions and policies aimed at promoting a resilient and sustainable workforce. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1038/s41598-026-35681-5.