Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model

使用人源化小鼠模型通过交叉验证分析人类对 PRINT 制备的纳米粒子的先天免疫反应

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作者:Gregory R Robbins, Reid A Roberts, Haitao Guo, Kevin Reuter, Tammy Shen, Gregory D Sempowski, Karen P McKinnon, Lishan Su, Joseph M DeSimone, Jenny P-Y Ting

From the clinical editor

The authors here fabricated hydrogel nanorods using the PRINT (Particle Replication In Nonwetting Templates) fabrication process. They tested the interaction of human immune cells with these particles and found no immunoreactivity. This finding would suggest that monodisperse PRINT particles of identical shape and size could serve a variety of clinical applications.

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