Abstract
OBJECTIVES: To quantify the tracheal, bronchial, and lung cancer burden attributable to particulate matter pollution in selected countries, and thereby provide evidence for context - specific public health interventions. METHODS: Based on Global Burden of Disease (GBD) 2021 data,we appliedJoinPoint to analyze the temporal trends from 1990-2021 in the burden of PM2.5 - attributable tracheal, bronchial, and lung (TBL) cancer in China, the US, Japan, and South Korea. And we explored the age, period, cohort effects and predicted future trends using the age-period-cohort mode and Bayesian analysis. RESULTS: Globally, the age-standardized mortality rate (ASMR) for TBL cancers due to PM2.5 exposure showed a declining trend with an average annual percentage change (AAPC) of-1.2811 from1990 to 2021, projections suggest continued decreases in ASMR in selected countries over the next 29 years, but a global increase is expected. CONCLUSION: Studies have demonstrated a global decline in the mortality burden attributed to bronchogenic carcinoma linked to PM2.5. Nevertheless, future projections indicate that the global burden of air pollution-related TBL cancer will rise, effective public health strategies are urgent to develop.