Abstract
OBJECTIVE: Children with acute respiratory tract infections (ARTIs) pose significantly burden on healthcare facilities due to high hospitalisation rates and mortality. However, limited epidemiological and clinical characteristics data on ARTIs in southeastern China during the COVID-19 pandemic exists. DESIGN: Cross-sectional. SETTING: Tertiary hospital associated with the First Affiliated Hospital, Fujian Medical University, China. PARTICIPANTS: 1007 hospitalised children diagnosed with ARTIs, aged 30 days to 15 years, were enrolled in this study from 1 January 2020 to 31 December 2021. OUTCOME MEASURE: The primary outcomes are the rate of pathogen infections in children with ARTIs. Secondary outcomes are the description of risk factors associated with ARTIs in children. RESULTS: Of the 1007 enrolled children, 28.2%, 42.2%, 21.8% and 7.7% were diagnosed with upper respiratory tract infection, bronchopneumonia, bronchitis and pneumonia, respectively. Mycoplasma pneumoniae (MP) was the most prevalent pathogen (31.9%), followed by influenza B virus (IFVB; 29.1%) and influenza A virus (IFVA; 19.1%). The study found that children under 1 year old (older than 30 days: OR(IFVB)=12.50; OR(MP)=8.53), children aged 1-3 years (OR(MP)=1.62), the winter season (OR(IFVA)=1.36), the time from symptoms onset to hospitalisation (OR(MP)=1.10) and increased precipitation (OR(LP)=1.01) were high-risk factors for ARTIs. CONCLUSION: This investigation offers significant insights into the prevalence and distribution of common pathogens among children experiencing ARTIs in the context of the COVID-19 pandemic. The discernment of high-risk factors linked to these pathogens enhances our understanding of the epidemiological characteristics of ARTIs in children.