Stimulation-Induced Dyskinesia in STN DBS Patients

STN DBS 患者的刺激诱发性运动障碍

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Abstract

BACKGROUND: Stimulation-induced dyskinesia (SID) is a poorly studied and usually transient manifestation of subthalamic deep brain stimulation (STN DBS) for Parkinson's disease (PD), which can be troubling for patients. OBJECTIVES: The aim of our study was to describe the features and management of SID in PD patients undergoing STN DBS. METHODS: We conducted a retrospective study among 86 STN DBS patients. Clinical features and volume of tissue activated (VTA) were correlated to SID occurrence. RESULTS: SID was identified in 28 (32.6%) patients and persisted for 6 months in six patients (7.0%). VTA overlap with the right motor STN was associated (P < 0.02) with SID. Weaning dopaminergic drugs and reducing the DBS amplitude were the most used strategies to control SID. CONCLUSIONS: SID is a relatively common complication of STN DBS and can be persistent. It often requires specific postoperative management strategies.

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