Definition of Sporadic Early-Onset Invasive Solid Organ Cancers in Adults

With a rising incidence globally, there is need to address a basic deficiency, namely, the lack of a clear definition of sporadic early-onset invasive solid organ cancers in adults. This manuscript discusses this need to have a unified understanding of what constitutes sporadic early-onset cancers in adults based on (epi)genetic, biological, and environmental influences with an aim to motivate clinicians and scientists to think about these cancers from a broader perspective when developing their own research programs.