Abstract
OBJECTIVE: To investigate the association between fat-to-muscle mass ratio (FMR) of whole body, arm, leg and trunk and the risk of benign ovarian neoplasm. METHODS: A total of 255 412 participants from the prospective cohort study United Kingdom biobank (UKB) were enrolled in the risk-related study of benign ovarian neoplasm. Cox proportional hazard model was used to evaluate the correlation between total and regional FMR and the risk of benign ovarian neoplasm. A priori stratified analysis was performed according to the body mass index (BMI) category to evaluate the correlation between FMR of whole body, arm, leg and trunk and the risk of benign ovarian neoplasm in people with BMI < 25 kg/m(2)and BMI≥25 kg/m(2), respectively. The restricted cubic plot was used to further explore the curve of FMR associated with the risk of benign ovarian neoplasm. Finally, subgroup analysis was performed on the age of the subjects (< 50 years, 50-59 years, ≥60 years) to explore the association between FMR and the risk of benign ovarian neoplasm at different ages. RESULTS: During a median 8.77 years of follow-up, we recruited 1 643 cases of benign ovarian neoplasms. After adjusting for demographic, reproductive, genetic, lifestyle, and hormone-related factors, total, arm, leg and trunk FMR were significantly positively correlated with the risk of benign ovarian neoplasm and higher than BMI with the risk of benign ovarian neoplasm, among which the whole body FMR had the strongest correlation with the risk of benign ovarian neoplasm (HR: 2.16; 95%CI: 1.67-2.79). Stratified analysis of FMR and the risk of benign ovarian neoplasm based on BMI showed that compared with people with BMI≥25 kg/m(2), people with BMI < 25 kg/m(2) had a stronger association between whole body, arm, leg and trunk FMR and the risk of benign ovarian neoplasm (P(interaction) < 0.05). The restricted cubic plot showed that the association between FMR of the whole body, arm and trunk and the risk of benign ovarian neoplasm had an opposite trend between normal weight and overweight/obese people. Subgroup analysis showed that the association between the whole body and leg FMR and the risk of benign ovarian neoplasm decreased with age (P < 0.05). Among them, leg FMR was associated with benign ovarian neoplasm in people younger than 50 years (HR: 2.38; 95%CI: 1.39-4.08). CONCLUSION: There is a positive correlation between the total, arm, trunk FMR and the risk of benign ovarian neoplasm, and the correlation is stronger in people with BMI < 25 kg/m(2) and women aged 40-50 years.