Efficacy of a single-dose topical formulation combining Fipronil, Moxidectin and Praziquantel against natural infestations of Notoedres cati, Otodectes cynotis and Felicola subrostratus in cats

单剂量外用制剂(含氟虫腈、莫昔克丁和吡喹酮)对猫自然感染的猫耳螨(Notoedres cati、Otodectes cynotis 和 Felicola subrostratus)的疗效

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Abstract

Lice and mange represent common ectoparasitic infestations in domestic cats, affecting their health and well-being. The study evaluated the efficacy of a topical formulation containing 12.5% fipronil + 0.83% moxidectin + 8.3% praziquantel against common feline ectoparasites Otodectes cynotis, Notoedres cati and Felicola subrostratus. For the ear mite study, a controlled trial was conducted on cats naturally infested with O. cynotis. For the other two parasites, field studies were conducted on naturally infested cats. Cats in the treated group received a single topical dose of formulation. Parasite counts were performed at various time points post-treatment to assess efficacy. The results demonstrated the formulation was highly effective against all three parasites, achieving 100% efficacy after 3 days of treatment. The product was well-tolerated and safe, making it a suitable option for the treatment of feline ectoparasitosis.

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