Abstract
BACKGROUND: Subjective well-being (SWB) encompasses both subjective happiness and objective factors. Anxiety and depression are increasingly recognized as contributing causes of functional dyspepsia (FD), yet the role of SWB in FD patients has been largely overlooked. This study aims to investigate the influence of SWB on anxiety, depression, symptom severity, and quality of life (QoL) in individuals with FD. METHODS: A total of 374 patients with FD were selected according to Roman IV criteria. Satisfaction with life scale and affect balance scale, Generalized anxiety disorders-7, Patient healthy questionnaire-9, Dyspepsia symptoms severity(DSS)and Nepean dyspepsia index (NDI) were used to assess SWB, anxiety, depression, symptoms severity and QoL, respectively. The results were analyzed using one-way analysis, t-test, Pearson's correlation, and multiple linear regression. RESULTS: Life satisfaction and emotional balance of FD patients were negatively correlated with DSS, anxiety, depression, and NDI for QoL(r=-0.148,-0.330,-0.325,-0.195, all p < 0.01), (r=-0.205,-0.545, -0.550, -0.357, all p < 0.001), respectively. Multiple linear regression showed that life satisfaction and emotional balance were influencing factors of anxiety (β= -0. 143, p = 0.001), (β= -0. 318, P < 0.001), and depression (β=-0. 122, p = 0.003), (β= -0. 287, p < 0.001), respectively. After removing anxiety and depression, life satisfaction and emotional balance were influencing factors of patients' DSS (β= -0.105, p = 0.049), (β= -0.180, p = 0.001), and QoL (β= -0.117, p = 0.023), (β= -0.329, p < 0.001), respectively. CONCLUSIONS: The SWB of FD patients is negatively associated with disease severity, anxiety, and depression, and positively associated with their quality of life. These results suggested that further strengthening SWB might help reduce symptom severity and improve the QoL of patients, which needs to be confirmed by future follow-up studies.