Abstract
BACKGROUND: Multiple myeloma (MM) is a malignant clonal disease originating from plasma cells. Patients with MM are prone to infections due to factors such as impaired immune function, bone marrow suppression, and anticancer therapy. A systematic review and meta-analysis of risk factors for infections in patients with MM provides evidence-based guidance for clinical risk assessment and intervention. METHODS: Search databases such as PubMed, Web of Science, Embase, Cochrane Library, from the establishment of the database to July 20, 2025, to include observational studies evaluating risk factors for infection in patients with MM. Use the NOS tool for literature quality assessment and perform meta-analysis using Stata 15.0 to combine odds ratios (OR) and 95% confidence intervals (CI). RESULTS: This study included 15 articles (1 case-control study and 14 cohort studies), involving 4,717 participants. The results of this meta-analysis suggest that age > 65 [OR = 1.72, 95% CI (1.18, 2.48)], male [OR = 1.70, 95% CI (1.11, 2.62)], smoking [OR = 2.97, 95% CI (1.94, 4.57)], International Staging System III [OR = 2.22, 95% CI (1.81, 2.73)], diabetes [OR = 2.67, 95% CI (1.74, 4.09)], immunomodulatory drugs [OR = 3.40, 95% CI (2.29, 5.07)], hemoglobin <10 g/dL[OR = 2.28, 95% CI (1.65, 3.16)], creatinine ≥ 2 mg/dL[OR = 2.80, 95% CI (2.07, 3.79)] was significantly associated with infection in patients with multiple myeloma. CONCLUSION: This systematic review and meta-analysis indicate that age >65 years, male gender, smoking, ISS stage III, diabetes, use of immunosuppressive agents, hemoglobin <10 g/dL, and creatinine ≥2 mg/dL are all significant risk factors for infection in MM patients. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD420251065706.