Abstract
Acute-on-chronic liver failure (ACLF) is a kind of complex syndrome characterized by acute deterioration of liver function on the basis of chronic liver disease, accompanied by organ failure and a high mortality rate. The International Society for Hepatology has proposed different definitions, diagnostic criteria, and treatment guidelines, which have led to differences in the clinical management of ACLF and underestimated the burden of the disease. Currently, there is no specific treatment for ACLF, and the overall prognosis is still not ideal. This article profoundly explores the problems existing in the interventional studies of ACLF and provides a new perspective for in-depth research on the pathogenesis and progression, the development of new intervention measures, the promotion of personalized treatment, and the formulation of more accurate diagnostic criteria and risk prediction models.