Short cationic antimicrobial peptides interact with ATP
短阳离子抗菌肽与 ATP 相互作用
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作者:Kai Hilpert, Brett McLeod, Jessie Yu, Melissa R Elliott, Marina Rautenbach, Serge Ruden, Jochen Bürck, Claudia Muhle-Goll, Anne S Ulrich, Sandro Keller, Robert E W Hancock
Abstract
The mode of action of short, nonhelical antimicrobial peptides is still not well understood. Here we show that these peptides interact with ATP and directly inhibit the actions of certain ATP-dependent enzymes, such as firefly luciferase, DnaK, and DNA polymerase. α-Helical and planar or circular antimicrobial peptides did not show such interaction with ATP.
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