Abstract
OBJECTIVE: To investigate the correlation between serum microRNA (miRNA) levels and the degree of macular edema in retinal vein occlusion (RVO) patients. METHODS: 180 RVO patients were divided into three groups based on macular edema severity: mild, moderate, and severe. Their serum miR-155-5p, miR-17-5p, and miR-375 levels were compared with 60 healthy controls. Pearson correlation analysis assessed the relationship between miRNA levels and clinical outcomes. RESULTS: miR-155-5p levels were significantly higher in RVO groups compared to controls, while miR-17-5p and miR-375 levels were lower. Increased severity of macular edema correlated with higher miR-155-5p and lower miR-17-5p and miR-375 levels. After treatment, miR-155-5p levels decreased, while miR-17-5p, miR-375, and visual acuity improved. Correlation analysis showed that changes in miR-155-5p were negatively correlated with visual improvement and macular edema resolution, while miR-17-5p and miR-375 were positively correlated with these outcomes. CONCLUSION: Serum miR-155-5p, miR-17-5p, and miR-375 levels are associated with macular edema severity in RVO. These miRNAs may serve as biomarkers for disease progression and prognosis, aiding personalized treatment strategies.