Abstract
We describe a case of a 74-year-old male patient with squamous cell carcinoma lung who was not a candidate for surgical resection due to tumor size and multiple comorbidities. The patient underwent percutaneous microwave ablation (MWA) followed by chemotherapy and targeted therapy. Post procedure, he developed tumor liquefaction and succumbed to hemorrhage. This case underscores the importance of individualized ablation planning for large tumors, optimization of ablation parameters, and careful timing of subsequent systemic therapy in order to reduce severe complications.