Abstract
BACKGROUND: There are huge differences in the disease burden of kidney cancer (KC) between countries and regions in Asia. Therefore, we conducted this study to investigate the KC burden and attributable risk factors in Asia. METHODS: We obtained data on the incidence, prevalence, mortality, disability adjusted life years, sociodemographic index (SDI), and attributable risk factors of KC in Asian countries and regions from 1990 to 2021 in the Global Burden of Disease database. Joinpoint regression was used to analyze the overall trend of the change in KC burden in Asia. The health inequalities of KC in Asia were evaluated. The correlation between SDI and KC burden was assessed. Autoregressive integrated moving average was used to predict the KC burden in the next 15 years. The age-period-cohort model evaluated the relative risk (RR) of the KC burden in different dimensions. In addition, frontier analyses were performed in this study. Finally, comprehensive analyses of the attributable risk factors of KC were performed. RESULTS: The KC burden in Asia showed a significant upward trend from 1990 to 2021. The KC burden was mainly concentrated in relatively wealthy countries and regions (high SDI). In the next 15 years, the KC burden would rise further. The RR of KC generally increased with age and period, and decreased with birth cohorts. The most concerning risk factor for KC was high body mass index (HBMI), and the KC burden attributed to HBMI also indicated a significant upward trend and was positively correlated with SDI. CONCLUSIONS: The KC burden in Asian countries and regions is still rising. Therefore, targeted medical interventions are needed to improve early diagnosis and treatment of KC.