Abstract
BACKGROUND: Breast cancer is one of the most common cancers among Pakistani women. It is mostly diagnosed at stage 2, requiring chemotherapy in certain cases. Chemotherapy is of two types: adjuvant and neoadjuvant. It can be recommended at any stage of cancer, either in early stages to shrink the tumor or in late stages to improve quality of life. The side effects may include weight loss, fatigue, hair loss, sores in the mouth, loss of appetite, nausea, vomiting, difficulty swallowing, throat problems, diarrhea, infections, and anemia, which can deteriorate health. Some women may experience weight gain during treatment, which is a risk factor for cancer recurrence. Chemotherapy has many side effects that can directly affect dietary patterns and worsen nutritional status. OBJECTIVES: This study aimed to evaluate the changes in dietary patterns of breast cancer patients during and after chemotherapy and assess how the side effects of chemotherapy affect their nutritional status. METHODOLOGY: Data were collected from 200 breast cancer patients undergoing chemotherapy at Jinnah Hospital, Lahore, using a questionnaire and the Patient-Generated Subjective Global Assessment (PG-SGA) screening tool. The questionnaire included sociodemographic information, questions about disease, treatment, and dietary recall. PG-SGA was used to screen for malnutrition and assess nutritional status. Data collection occurred from September to December 2023. RESULTS: Most participants were female (99%), married (73.5%), and of low socioeconomic status (60.5%). The common stage of cancer was stage 3, and neoadjuvant chemotherapy was recommended for most participants. Effects on body weight varied, with some experiencing weight loss, others weight gain, and some no change. Side effects such as vomiting, nausea, diarrhea, dry mouth, loss of appetite, altered taste and smell, and anemia were commonly reported. Most participants were moderately malnourished or suspected of malnutrition and needed intervention for symptom management. A majority (82%) were overweight or obese according to BMI, indicating a higher risk of cancer recurrence. Participants' dietary intake mainly consisted of carbohydrate- and protein-rich foods during treatment. CONCLUSION: The side effects of chemotherapy varied among patients. The impact on body weight also differed, with some experiencing weight loss, others weight gain, and some no change. Regarding nutritional status, most patients were moderately malnourished, while a few were severely malnourished.