Abstract
OBJECTIVES: Aging mechanisms at both cellular and organismal levels remain poorly understood, as do the factors influencing the variability in aging rates across organs and individuals. Our work aims to identify the key biological pathways that drive aging, determine the most relevant biomarkers of biological aging, and uncover actionable mechanisms to improve risk prediction for unsuccessful aging. METHODS: To achieve these objectives, we employ a structured approach that includes (a) investigating the molecular and cellular mechanisms underlying aging, (b) identifying and validating biomarkers associated with biological aging, and (c) assessing potential therapeutic targets that could modulate aging-related processes. These efforts are being carried out within the framework of the Age-It initiative, leveraging interdisciplinary methodologies and advanced analytical tools. RESULTS: Ongoing studies within Age-It are generating insights into aging-related pathways and biomarkers. Preliminary findings highlight specific molecular signatures associated with biological aging and suggest potential intervention points for mitigating age-related decline. DISCUSSION: Understanding the biological underpinnings of aging will enhance our ability to predict and potentially modify aging trajectories. By identifying reliable biomarkers and actionable pathways, this research may contribute to the development of targeted interventions to promote healthy aging. The Age-It initiative represents a collaborative effort to translate these findings into practical applications for aging research and health care policy.