Abstract
This research intends to explore the association of the triglyceride-glucose (TyG) index with cardiovascular disease (CVD) death, stroke, myocardial infarction (MI), heart failure (HF) and peripheral arterial disease (PAD) in non-diabetic hypertension. This post hoc analysis uses data from a large-scale randomised controlled trial (RCT) study-Systolic Blood Pressure Intervention Trial (SPRINT), and we used Cox proportional hazards regression to explore the relationship between TyG and different CVDs. This longitudinal analysis of 9323 participants revealed a significant positive association between the TyG index and CVD death (HR 1.91, 95% CI 1.34, 2.73), HF (HR 1.43, 95% CI 1.05, 1.94), MI (HR 1.30, 95% CI 1.00, 1.69), stroke (HR 1.60, 95% CI 1.16, 2.21) and PAD (HR 1.78, 95% CI 1.30, 2.44). This positive correlation was consistently observed across different subgroups. Trend tests were significant for CVD death, heart failure, MI, stroke and PAD (p < 0.05). In non-diabetic hypertensive patients, a higher TyG index was associated with a higher risk of CVD (CVD death, stroke, HF, MI, PAD).