Evaluation of Ebola virus inactivation procedures for Plasmodium falciparum malaria diagnostics

评估埃博拉病毒灭活程序对恶性疟原虫疟疾诊断的评估

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作者:Rachel Lau, Amanda Wang, Ann Chong-Kit, Filip Ralevski, Andrea K Boggild

Abstract

Plasmodium falciparum malaria is highly endemic in the three most affected countries in the current epidemic of Ebola virus disease (EVD) in West Africa. As EVD and malaria are clinically indistinguishable, both remain part of the differential diagnosis of ill travelers from returning from areas of EVD transmission. We compared the performances of a rapid diagnostic test (BinaxNOW) and real-time PCR with P. falciparum-positive specimens before and after heat and Triton X-100 inactivation, and we documented no loss of sensitivity.

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