Chronic venous disease patients show increased IRS-4 expression in the great saphenous vein wall

慢性静脉疾病患者的大隐静脉壁中 IRS-4 表达增加

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作者：Miguel A Ortega, Oscar Fraile-Martínez, Cielo García-Montero, Fernando Ruiz-Grande, Silve Barrena, Hector Montoya, Leonel Pekarek, Sofia Zoullas, Miguel A Alvarez-Mon, Felipe Sainz, Angel Asúnsolo, Julio Acero, Melchor Álvarez-Mon, Julia Buján, Natalio García-Honduvilla, Luis G Guijarro
期刊：Journal of International Medical Research影响因子：1.400
时间：2021起止号：2021 Sep;49(9):3000605211041275.
doi：10.1177/03000605211041275研究方向： 信号转导

Conclusions

IRS-4 may be implicated in CVeD development and progression. Therefore, IRS-4 could be a potential diagnostic or therapeutic target for patients with this condition.

Methods

We conducted a histopathological study to analyze IRS-4 protein expression in CVeD patients compared with healthy controls.

Results

Our results demonstrate a significant increase in IRS-4 expression in VV tissue. Conclusions: IRS-4 may be implicated in CVeD development and progression. Therefore, IRS-4 could be a potential diagnostic or therapeutic target for patients with this condition.

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