Synthetic Applications of Hydroxamic Acids and Their Derivatives in Organic Chemistry

Hydroxamic acids and their derivatives are a versatile class of organic compounds with broad utility in synthetic chemistry. This review highlights key synthetic transformations involving these molecules, covering important reactions such as their use in Weinreb amide chemistry, rearrangement processes, C-H activation directed by hydroxamate groups, their role as precursors to N-centered radicals and aza-oxyallyl cations, reduction reactions, and umpolung transformations initiated by the N-O bond cleavage.