Abstract
Skin aging causes cumulative structural, physiological, and progressive skin changes, as well as wrinkles, uneven skin tone, elasticity loss, and skin thinning. We performed a systematic review of nine studies involving 278 participants to assess the efficacy and safety of the stable, hybrid cooperative complexes of high molecular weight hyaluronic acid (HCC-HA) and low molecular weight hyaluronic acid used in Profhilo® and Profhilo® Body (IBSA Farmaceutici Italia Srl, Lodi, Italy) on skin laxity, elasticity, hydration, density, wrinkle severity, and facial volume loss. We found that treatment with Profhilo® and Profhilo® Body led to a statistically significant change or a trend toward an improvement in mean viscoelasticity, elasticity, or plastoelasticity parameters (malar/submalar regions of the face, neck, inner arms, abdomen, and hands); skin hydration (malar/submalar face regions, the neck, inner arms, abdomen, and knees); skin density parameters (face, neck, inner arms, abdomen, hands, and knees); skin laxity (neck, inner arms, abdomen, knees, and hands); and Wrinkle Severity Rating Scale and Facial Volume Loss Scale scores (face). Photographic evidence showed improved skin turgor, tone, and texture, reduced nasolabial fold depth and wrinkles, and overall amelioration. Adverse events (i.e., bruising, edema, a light pinching sensation, a small bump, localized hematomas) were mild, expected, and usually resolved within 72 hours. Profhilo® and Profhilo® Body can improve skin laxity, hydration, elasticity, and density while reducing wrinkles and facial volume loss.