Abstract
OBJECTIVE: To investigate the clinical efficacy of negative pressure wound therapy (NPWT) in the treatment of odontogenic cervical Necrotizing fasciitis (CNF). METHODS: Sixteen cases of odontogenic cervical necrotizing fasciitis were randomly divided into observation group and control group after routine debridement and disinfection. The patients in the control group were treated with drainage tube and regular dressing changes, while those in the observation group were treated with NPWT. The therapeutic effects of the 2 groups were compared. RESULTS: The frequency of operation, treatment length, and cost of treatment in the observation group were significantly less than those in the control group ( P <0.05). During the treatment, the VAS (visual analog scale of pain) in the observation group was significantly lower than that in the control group ( P <0.05). The levels of WBC, CRP, PCT, IL-6, and TNF-α in the observation group were lower than those in the control group ( P <0.05). The levels of Il-10 and VEGF in the observation group were higher than those in the control group ( P <0.05), the difference was statistically significant. CONCLUSIONS: The condition of odontogenic cervical necrotizing fasciitis progresses rapidly. Compared with conventional drainage and dressing change, NPWT can control infection in a short time, reduce operation frequency and treatment cost, and promote wound healing, shorten the treatment time, ease the pain of patients, improve the quality of life. The therapeutic scheme is safe, effective, and suitable for clinical application.