Relation of mucous membrane alterations to oral intake during the first year after treatment for head and neck cancer

头颈癌治疗后第一年内黏膜改变与口服摄入的关系

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作者:Barbara Roa Pauloski, Alfred W Rademaker, Jerilyn A Logemann, Donna Lundy, Michelle Bernstein, Carrie McBreen, Daphne Santa, Angela Campanelli, Lisa Kelchner, Bernice Klaben, Muveddet Discekici-Harris

Background

Acute oral mucositis is associated with pain and impaired swallowing. Little information is available on the effects of chronic mucositis on swallowing.

Conclusion

Lack of association with pain was attributed to the absence of ulcerations. Continued impairment of oral intake during the first year posttreatment may be related to oral mucosal changes and other factors.

Methods

Sixty patients treated for cancer of the head and neck were examined during the first year after their cancer treatment. Oral mucosa was rated with the Oral Mucositis Assessment Scale. Stimulated whole-mouth saliva, oral pain rating, percent of oral intake, and 2 subscales of the Performance Status Scale for Head and Neck (PSS-HN) cancer were also collected.

Results

Mucositis scores and pain ratings decreased over time while functional measures of eating improved over time. Reduction in chronic mucositis was correlated with improved oral intake and diet.

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