Abstract
Singapore has advanced in precision medicine, which is largely based on genetic testing and sequencing, yet its safeguard against genetic discrimination (GD) is limited to a non-binding insurance moratorium, with no protections in employment. This study examined the prevalence of self-reported GD and factors influencing willingness to undergo genetic testing in Singapore. A cross-sectional survey assessed experiences of GD, awareness of protections and testing willingness. Twenty percent reported GD in insurance and 9% in employment. The majority identified existing safeguards incorrectly. Sixty-four percent expressed willingness to undergo medically indicated genetic testing. Willingness was positively associated with education, trust in healthcare and perceived fair treatment and negatively associated with age, parental status, deterministic thinking and cultural-religious beliefs. The results highlight that, though policymakers aim to mitigate GD in Singapore, enhanced legal protections and public education are needed to support equitable access to genetic testing.