Abstract
In this multicenter cross-sectional study of two different approaches to universal SARS-CoV-2 admission testing, hybrid testing (SARS-CoV-2 for asymptomatic and multiplex for symptomatic) resulted in increased isolation days due to ordering errors among symptomatic patients. Universal multiplex testing minimized such errors while detection of asymptomatic non-SARS-CoV-2 viruses remained infrequent.